Day 1 :
Keynote Forum
Yoshinori Hayakawa
Toin University of Yokohama, Japan
Keynote: Universal vaccine and artificial pandemics by infectious attenuated live vaccine to save people from dangerous new influenza pandemic
Biography:
Abstract:
- Endocrinology and Diabetes | Endocrine Disorders | Diabetes: Diagnosis and Treatment | Diabetic Diet and Nutrition
Session Introduction
Soo Kyoung Choi
Yonsei University, Republic of Korea
Title: AdipoRon, adiponectin receptor agonist improves vascular function in the mesenteric arteries of type 2 diabetic mice
Biography:
Soo Kyoung Choi has pursued her PhD from Yonsei University and Postdoctoral studies from Tulane University. She is the Research Assistant Professor in Department of Physiology at Yonsei University. She has published more than 22 papers in reputed journals.
Abstract:
Adiponectin is one of the most abundant adipokines secreted from adipose tissue. An orally active synthetic adiponectin receptor agonist, adipoRon has been suggested to ameliorate insulin resistance, myocardial apoptosis, and pancreatic tumor. It has been reported that adiponectin directly induces vascular relaxation however; the chronic effect of adipoRon in the vascular dysfunction in type 2 diabetes has not been studied yet. Thus, in this study, we examined whether adipoRon improves vascular function in type 2 diabetes and what mechanism is involved. Ten to 12-week old male type 2 diabetic (db-/db-) mice were treated with adiponectin receptor agonist (adipoRon, 10 mg/kg/everyday by oral gavage) for 2 weeks. Isolated mesenteric arteries were mounted in the arteriography and arterial diameter was measured. And western blot analysis was assessed. Pressure-induced myogenic response was significantly increased, whereas endothelium-dependent relaxation was significantly reduced in the mesenteric arteries from type 2 diabetic mice. Interestingly, treatment of adipoRon normalized potentiated myogenic response. However, endothelium-dependent relaxation was not affected by treatment of adipoRon. The expression levels of adiponectin receptor 1, 2 and APPL 1, 2 were increased in the mesenteric arteries from Type 2 diabetic mice and treatment of adipoRon did not affect them. Interestingly, adipoRon treatment increased the phosphorylation level of AMPK and decreased phosphorylation of MYPT1 in the type 2 diabetic mice while there was no change in the level of eNOS phosphorylation. The treatment of adipoRon improves vascular function in the mesenteric arteries from type 2 diabetic mice through endothelium-independent mechanism. It is suggested that MLCP activation through reduced phosphorylation of MYPT1 might be the dominant mechanism in the adipoRon-induced vascular effect.
Goutam Kumar Acherjya
Upazila Health Complex, Bangladesh
Title: The insight of adolescent diabetes mellitus
Biography:
Goutam Kumar Acherjya is a Junior Consultant of Medicine in the Upazila Health Complex, Bagherpara, Jashore, Bangladesh. He has obtained MBBS degree and completed Post-graduate Fellowship (FCPS) in Internal Medicine. He has several global publications. His areas of interest are diabetes, effect of metabolic disorders on CNS.
Abstract:
Diabetes mellitus is an endocrine disorder where hyperglycemia occurs due to defect in insulin secretion, insulin action or both. Recently WHO member countries have given more emphasis on the Non-Communicable Diseases (NCDs) rather than the communicable diseases for the sustainable developmental goal due to increased rate of long-term morbidity, mortality and high cost health related resources expenditure. Diabetes mellitus is one of the four priority NCDs related to both macrovascular and microvascular complications causing blindness, kidney failure, heart attacks, stroke and lower limb amputation. Due to genetic predisposition, environmental factors, positive family history, obesity, inadequate physical activities, sedentary lifestyle, rapid urbanization and unhealthy food practice the global prevalence of diabetes is dramatically increasing not only in the adult and older aged group but also in the children and adolescent aged group. In near future many countries of the globe may face a major public health challenge more than our anticipation due to increased prevalence of adolescent diabetes which is directly related to early onset risk factors and complications. There are high up negative significant effects on the quality of life, employment and health related expenditure when diabetes affects in this age group. So necessary steps and strategic plan should be designed for the earlier detection and intervention of adolescent diabetes.
Biography:
Ahmad Ishtiaq has completed his MD at the age of 24 years from International School of Medicine, Bishkek. His specialty is gastroenterology and worked as research fellow at graduate School of Medicine, Juntendo University, Tokyo, Japan. Currently, He is the PhD candidate, at Juntendo University dept. of Public health. He is working on Pfizer Type 2 Diabeties project in Thailand and mayanmar. He has published a systematic review on Childhood obesity and nutrition transition in Asian countries.
Abstract:
Diabetes prevalence has been rising more rapidly in low and middle income countries. In Myanmar WHO STEP survey, a high intake of FV (fruit and vegetable) was associated with lower odds of hypertriglyceridemia among men and women. It was also associated with cholesterol levels, negatively among women and positively among men. Myanmar's traditional food tends to have a lot of fats and carbohydrates. Recently, dietary habits of Myanmar residents have been westernizing. More than 200,000 deaths annually among the Thai population are owing to chronic non-communicable diseases and about 30,000 deaths are owing to diabetes, a leading cause of death in Thailand. With rapidly emerging T2DM, prevalence among adults has risen from 2.3% in 1991 to 8.0% in 20155. Over 4 million Thai adults live with diabetes, making it the top cause of disability-adjusted life years lost for Thai women and the seventh cause for men. In total 600 T2DM patients will be recruited (both side) to have face to face questioners interview dietry habits, physical activity, salt and sugar measurement from the food. This study will investigates the occurrence of DM in citizens of the Yangon Region, Myanmar and Chiang-mai, Thailand. The comparison of pre-test results of the actual dietary habits and activity habits of adult of Myanmar and Thailand showed the factor that the prevalence of T2DM in urban Myanmar is extremely high.
Huang Wei Ling,
Medical Acupuncture and Pain Management Clinic, Brazil
Title: Why are diabetic patients still having hyperglycemia despite diet regulation, antiglycemic medication and insulin?
Biography:
Huang Wei Ling, Chinese raised in Brazil since the age of one, graduated in medicine, specializing in infectious and parasitic diseases, a General Practitioner, Parenteral and Enteral Medical Nutrition Therapist, Acupuncture and Pain Menagement. She is the owner of the Medical Acupuncture and Pain Management Clinic, and since 1997 has been presenting her work worldwide concerning the treatment of various diseases, using techniques based on several medical traditions around the world.
Abstract:
Diabetes and its complications were responsible for 8.8% of deaths worldwide in 2017. Many of those deaths could be avoided. Western medicine manages the disease with lifestyle changes and medication. The aim of this work is to demonstrate how in Traditional Chinese Medicine, all diseases are associated with the Yin and Yang imbalance, including diabetes. Although western medicine and Traditional Chinese medicine (TCM) share the diabetes treatment goals of reducing symptoms and preventing complications, their approaches to conceptualizing, diagnosing, and treating the disease are very different. The methods used in this study were two case reports and bibliographic researches of TCM’s medical literature and Five Elements Theory on the pathophysiology of energy imbalances in diabetes, which lead to the manifestation of the clinical symptoms. The treatment results, looking from the energy point of view, treat the individual as a whole; not only treating the disease but the entire body, as recommends Hippocrates, the father of Medicine. After rebalancing the body’s energy, taking awareness and precaution about internal (emotional) triggers, dietary factors and external (climatic) triggers, the symptoms’ improvement is noticible. Concluding, when looking at patients as a whole, from the point of view of Yin and Yang energy and Five Elements Theory, we can analyze aspects of the diet normally recommended and the use of hypoglycemic medication and/or insulin, and have a greater balance of hyperglycemic diabetic patients, treating them according to the energy point of view with dietary recommendation, acupuncture, etc.
Biography:
Sanjay P Gandhi has pursued his MBBS and MD from B J Medical College, Pune, India. He has teaching experience of about 3 years and has been practicing as Physician for almost 30 years. He has been running a charitable organization ‘Diabetes Patient Club’ since 2002 and A1c Club’ since 2011, very successfully. He has written articles in India Today magazine for 3 years. He has conducted short one day picnic programs for Diabetic patients and their better halves for 9 consecutive years in and around Pune in India.
Abstract:
Aim: Can we change the Economics of insulin pump Therapy in India and other developing countries? We want to find the answer to this question, thereby making the pumps available to the needy T1DM and T2DM patients at much lower prices than the present costs. Methods: We have studied the total nine patients using the insulin pumps at our centre, Gandhi Clinic in Pune, India. Out of nine patients, four are IDDM and others are T2DM. We have also tried IPT in a lady retired teacher who is 72 years old (T2DM). Out of 9 patients, three Insulin Pumps are lying at our clinic, two pumps due to sad demise of the patients and one pump due to the adverse advice by another doctor. The relatives of the patients are at double loss, moneywise and person loss. Results: Many healthcare professionals compare a car with pump. Frequently, we say if someone can afford a car then he would easily afford the insulin pump. In India, we have a scheme to buyback and refurbish the used cars by the manufacturer and the resale of the same car is possible at a much lower cost than the cost of the new car of same brand and the manufacturer. Discussion: Since the fact prevails in India and developing countries that availability of insulin is a difficult task at times, insulin pump therapy is a farfetched dream. There must be more than few thousand pumps in India which are resalable. These pumps can be refurbished and can be made available to the needy and willing patients of T1DM as well as T2DM patients in these resource constrained countries. We want the whole world brain volume to think on this sensitive issue.
Sovann Peng
Community Medical Center, Cambodia
Title: Metabolic risk profile of pre-diabetes in an urban medical center in Cambodia
Biography:
Sovann Peng has pursued his Diploma of Doctor of Medicine from International University, Phnom Penh, Cambodia. He has been working as Diabetes Program Coordinator and Junior Physician at Community Medical Center, Phnom Penh, Cambodia.
Abstract:
Introduction: Pre-diabetes is associated with insulin resistance and increased risk of cardiovascular disease. Pre-diabetes may precede Type 2 Diabetes Mellitus (T2DM) by many years, allowing for potential intervention. The prevalence of diabetes is increasing around the world, especially in developing countries. Characteristic of patients with pre-diabetes in Cambodia have not previously been reported. Aim: To determine the clinical characteristics of patients with pre-diabetes who presented for health care at the Community Medical Center (CMC) in Phnom Penh, Cambodia and to determine if any sex differences exist. Method: A retrospective study of 207 patients found to have pre-diabetes (HbA1C from 5.7% to 6.49%), who had a complete biophysical profile (age, gender, BMI, abdominal girth, blood pressure and lipid profile) between July 2015 and July 2018. Result: Physical: Among 207 patients, women represented 72%. Men and women had similar mean of age around 60. Both genders had similar high rates of overweight and hypertension. Women had significantly greater rates of elevated gender corrected abdominal girth (p-value <0.001). Labs: Both women and men had high rates (approximately 80%) of elevated lipid values (total cholesterol, LDL and triglycerides). Women had significantly higher total cholesterol levels than men (p=.04). HDL levels were not measured. Men and women had similar A1C levels (mean around 6.2). Conclusion: This is the first study to characterize pre-diabetes in Cambodia. Patients with pre-diabetes have high risk lipid profiles and hypertension. Women have more central adiposity than men, which may adversely impact progression to diabetes. Patient with pre-diabetes in Cambodia may benefit from aggressive management of metabolic risk factors.
Nayomi Shermila Jayasinghe
Bairnsdale Regional Health Service, Australia
Title: Dengue fever associated cerebral hemorrhages, a rare, poorly understood entity in an era of dengue epidemic: A case series and literature review
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Valentina A Divocha
Lugansk State Medical University, Ukraine
Title: Presence of cellular components in vaccines and immunobiological drugs
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Goutam Kumar Acherjya
Upazila Health Complex, Bangladesh
Title: Antimicrobial resistance-A global public health challenge
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Leila Azimi
Shahid Beheshti University of Medical Sciences, Iran
Title: A report of rate and antibiotic resistance patterns of global threatening bacteria in Iran
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Huang Wei Ling
Medical Acupuncture and Pain Management Clinic, Brazil